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KMID : 0364820160520020226
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Korean Journal of Microbiology
2016 Volume.52 No. 2 p.226 ~ p.229
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Inhibition of cell wall synthesis in Cryptococcus neoformans and decrease of skin allergy induced with Alternaria alternata in mouse model by a chitinase from an inky cap
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Kang Yu-Ri
Choi Hyoung-T.
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Abstract
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The growth of two different fungal species, human pathogenic Cryptococcus neoformans and plant pathogenic Alternaria
alternata were inhibited by a chitinase (Chi2) expressed in the autolysing tissue of Coprinellus congregatus. The cell wall thickness was reduced (up to 32%) in C. neoformans compared with that of normal cell, and polysaccharide fibers located outside of the cell wall were also severely removed. The hyphal growth of A. alternata on agar plate was stopped by the enzyme. The allergic inflammation induced by A. alternata was reduced by the enzyme reaction when compared with untreated control in a mouse model.
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KEYWORD
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Alternaria alternata, Cryptococcus neoformans, allergy, chitinase
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